Clinical, Cellular & Molecular Biology of Autoimmune Disorders–Introduction
نویسندگان
چکیده
(MHC) control to present autoantigens, antigenic mimicry, altered proteins of the host, apoptosis and aging [1]. Beside this, several genetic factors and loci like non-HLA genes and autoimmune susceptibility loci, tumor necrosis factor-alpha (TNF-α) and forkhead box P3 (FOXP3) have been associated with susceptibility to autoimmune diseases [2]. Some common autoimmune diseases are rheumatoid arthritis, multiple sclerosis, diabetes, cardiomyopathy, antiphospholipid syndrome, myasthenia gravis, Crohn’s disease, Graves’ disease, psoriasis and alopecia. Moreover, such disorders may influence other non-autoimmune diseases as well e.g., Duchenne’s muscular dystrophy and arthrosclerosis [3]. Autoimmune disorders as a group are among the most expensive diseases faced by society today however, the total societal disease burden is difficult to evaluate due to their diverse effect on human health from most debilitating and chronic to less serious and temporary.
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